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pentobarbital will lower the extent or impact of diazepam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Strong or reasonable CYP3A4 inducers may enhance rate of diazepam elimination; for that reason, efficacy of diazepam may be lowered.pentobarbital will lessen the level or impact of buprenorphin